Top medical researchers have discovered new HIV antibody that can suppress the virus for about six months without taking the pills every day.
The current study made use of a group monkeys, infused with a broadly neutralizing antibody to HIV combined with an immune stimulating compound.
The findings was disclosed at the 25th Conference on Retroviruses and opportunistic Infections in Boston, it lend a clue to strategies that attempt to achieve sustained drug-free viral remission in people living with HIV.
The research was also giving credibility to by the support of U.S National Institute of Allergy and Infectious Diseases (NIAID), the study targeted the viral reservoir, populations of long-lived latently infected cells that harbor the virus and that lead to resurgent viral replication when suppressive therapy was stopped.
Also, scientists from Beth Deaconess Medical Center infected 44 rhesus macaques with simian human immunodeficiency virus on nonhuman primate studies. They initiated daily antiretroviral therapy (ART) during acute infections to suppress the virus to below detectable levels in the monkeys’ blood.
After a 96- week treatment, the monkey was divided into four equal groups, and continued to administer the ART for 16 additional weeks, with the aim to determine whether the combination of HIV antibody and immune stimulant could reduce the viral reservoir while the virus replication was well controlled by the ART.
After discontinuation of the ART, research as it that the virus rebounded in the blood of 11 monkeys that neither received HIV antibodies or immune stimulant after a median of 21days.
The experts also said that six out of the 11 monkeys that received the therapy combination showed a delayed viral rebound after a median of 112 days, the remaining five did not rebound for at-least 168 days.
The principal Investigator of the study, Dan Barounch said that their findings suggest that the development of interventions to articulate and eliminate a fraction of the viral reservoir might be possible.
Also, the researchers revealed that compared with the antiretroviral therapy which needs to be taking daily, this new discovery of antibodies to HIV tend to last longer in the body, and have shown promise for longer acting HIV therapeutics and prevention.
With this new discovery, hope will be restored to the life of people living with the virus because it will bring much longer life to them and also eliminate the everyday taking of pills by the time the administration commences.
New fears over animal tuberculosis infection in Nigeria
– over 10% of cows and 43% of herds have tuberculosis
Photos of uncooked meat, sold in some markets in Nigeria, capture a rising threat to public health coming from indiscriminate slaughter and consumption of animals infected with tuberculosis. The photos are emerging barely three years after a study by World Data Atlas showed that tuberculosis death rate of Nigeria had increased from 60 cases per 100,000 people in 2002 to 62 cases per 100,000 people in 2016, recording an annual death rate of 0.28 %. A similar study by researchers at the Department of Veterinary Medicine, University of Ibadan, conducted between 2013 and 2015 revealed that in Nigeria, over 10 percent of cows and 43 percent of herds have tuberculosis.
According to the World Health Organisation (WHO), despite the significant progress made over the last decades, TB continues to be a top infectious killer disease worldwide, claiming over 4,500 lives a day. Nigeria is one of the countries on the list of 30 high burden TB, TB/HIV and MDR-TB countries as compiled by the World Health Organisation (WHO). Nigeria emerged 7th amongst the high TB burden countries globally and 2nd in Africa. The problem of TB in Nigeria has been made worse by the issues of drug-resistant tuberculosis and the HIV/AIDS epidemic. With animal tuberculosis thrown into the mix, there can only be a rising index.
How TB is transmitted from animal to human
Tuberculosis can be transmitted from animal to animal, animal to human and human to animal, according to Ms Daphne Peter Habila, a veterinary doctor with Paws and Claws Veterinary Consult in Abuja who spoke to SATELLITE TIMES.
“Animal tuberculosis is a disease caused by organisms belonging to the family Mycobacterium tuberculosis complex(MTC). It affects animals such as cattle, sheep, goat, dog, birds, horses and even wild animals such as buffalo, bison, elk, lions, etc. The disease is zoonotic – which means it can be transmitted from animals to humans, humans to animals, as well as between humans and between animals. Tuberculosis is a highly communicable disease and humans can become infected when they consume unpasteurized dairy products from infected animals, raw or undercooked infected meat, when there is a break in the skin and the organism finds its way into the body and through inhalation of the organism from an infected animal.”
Difference between human to human TB and animal to human TB
“The major difference between human to human and animal to human TB is the species of Mycobacterium organism involved and their routes of transmission. Tuberculosis is life-threatening but often not treated in animals. Although the primary organism responsible for human tuberculosis is Mycobacterium tuberculosis, humans can equally be infected with other species such as Mycobacterium bovis which causes bovine tuberculosis in cattle and is equally fatal in humans especially when an individual is immune-suppressed.”
Identifying TB infected meat
“A TB infected organ can be identified by the appearance of whitish nodules on the surface (resembling small stones) which makes a gritty sound (like cutting through sand) when a knife is used to cut through the meat. Nigerians should be educated on the dangers of consuming TB infected products by knowing how to identify TB infected tissues using the characteristic nodules (as shown in the picture above).”
“Since animal tuberculosis is equally as fatal as human tuberculosis, intervention should be aimed at controlling and ultimately eradicating the diseases in both animal and human populations. In animals, the test and slaughter policy, that is meat inspection at abattoirs, should be strictly implemented; humans who are more at risk such as veterinarians, herders, butchers, should be periodically screened, tested, and positive persons treated. Very importantly, infants should be given the Bacillus Calmette-Guerin (BCG) vaccine early in life. Also, there should be regular surveillance of both human and animal population alike. Workers at slaughterhouses should regularly be educated on the dangers of consuming and selling infected animal products.
And the government should consider paying compensation to those whose animals will be condemned as a result of TB infection, the same way compensations were paid to poultry farms affected by bird flu.”
Animal TB and HIV/AIDS interventions
According to the WHO, HIV-infected people are 30 times more likely to contract TB than those who have not acquired HIV. In trying to understand what happens when TB comes first before HIV, SATELLITE TIMES spoke to Steve Aborisade, the Advocacy and Marketing Manager at AIDS Healthcare Foundation (AHF). Aborisade said that if TB comes first, it can impact on HIV in the sense that a high prevalence of TB can lead to more incidences of new HIV infection.
“Any condition resulting in weakened immunity automatically makes HIV transmission highly probable. TB is, however, an opportunistic infection in people living with HIV, but they are prone to getting TB because of their low immunity. Getting TB in animals is not impossible but rare of the incidences we have. Naturally, millions of people have latent TB in them but not active TB, and it can be anybody since it is airborne. But it may become active once the immunity is weakened by malnutrition, alcoholism and other diseases.
“We have very effective treatment even though we are now faced with multi-drug resistance TB. I think the angle of TB from consumption of animals should be carefully handled, not to create unnecessary panic for a disease which little is known by majority of the people,” Aborisade cautioned.
Hunger, malnutrition threaten lives of IDPs in Benue
– Report by Jireh Doo Foundation reveals 88,667 children at risk
Conditions of Internally Displaced Persons (IDPs) worsen in Benue State. Hunger, acute malnutrition, and sickness are among the most challenging plights faced by IDPs.
While 23,940 children are severely malnourished with possible risks of fatality, a total number of 88,667 are at risk, a recent report on the conditions of IDPs in the State has shown.
The report made available by Jireh Doo Foundation revealed 112,617 as the number of vulnerable children between ages 0-59 months displaced by farmer/herder clashes in the state.
According to the report, IDP profiling in Makurdi, Guma, and Logo were conducted from April 4, 2018 to May 30, 2018, while Okpokwu, Agatu, Gwer West, and Kwande were profiled from September 19, 2018 to October 13, 2018.
The Local Government Areas (LGAs) covered during the survey include – Agatu, Makurdi, Guma, Logo, Gwer West,and Kwande. The survey which took statistics of households and household sizes, among other demographic considerations, also revealed the number of vulnerable pregnant women, nursing mothers, the aged, injured, and sick.Results of the survey was made a public document at an event held in Abuja Wednesday, (February 6) with development partners, the media and other stakeholders in attendance.
Fielding questions during the event, a representative of Benue State Emergency Agency (BSEMA), Shior Emmanuel said food meant for the IDPs is not in short supply but distribution is impeded by the National Emergency management Agency (NEMA).
Other crises faced by the 483,692 IDPs include, Gender Based Violence, lack of medical care, poor sanitation, increase in crime rate, trauma and mental breakdown, the report showed.
The report by Jireh Doo Foundation aims to draw the attention of International Partners, the Federal Government, and local humanitarian organizations to respond and intervene in the current humanitarian crisis in the State.
Whistleblower hounded for exposing corruption in Federal Medical Centre Keffi
-millions diverted to private pockets, unqualified lab scientists employed in haematology unit
A senior Medical Laboratory Scientist on grade level 10 at the Federal Medical Centre Keffi, Umeh Gabriel Uzoma, has known no peace for blowing the whistle on a cabal of corrupt officials who for years set up different conduits, funnelling government money into private accounts.
Since exposing what turned out to be serial corruption, life has become a living hell for the whistleblower whose salary payment was frozen pronto as he faces a technical dismissal.
Umeh has suffered multiple harassment and indignities to a point a female colleague once spat in disgust, asking him: “what are you still doing here?” That incident was succeeded by “violent assaults from my head of unit, Mrs. Afolake Bello, who held my phone and asked me to leave the laboratory.
Umeh’s actions as a whistleblower was inspired by a circular with Reference FMC/KF/ADM/538 from the office of the Medical Director to all HODs/Units. The circular, dated 23 January 2017 has the heading: ILLEGAL COLLECTION OF CASH FROM PATIENTS.
It reads: “Management has observed that some staff are in the habit of collecting cash illegally from patients for some services rendered. No staff should collect cash under any circumstances from patients but to direct such patients to pay at the bank.”
The circular goes on to say: “It is the responsibility of the Head of Department/Unit to ensure as a matter of duty that all services rendered are properly captured and payment made via the EMR platform. Any officer that violet this will be meted with proper sanctions. This should be considered as the last warning.”
The whistler exposed how cash was collected from patients and remitted to the HOD, Laboratory Services, Mr. Haruna Muhammad Aminat and Head of Unit Mrs. Afolake Bello Saidat including cash for cross matching of blood and from sales of pints of blood.
He also exposed how unqualified ‘cover-up’ staff were accommodated as part of the ring perpetrating illegal activities in the Laboratory Services Department of the hospital under Mrs. Afolake Bello Saidat, head of the Haematology unit and the HOD, Mr. Haruna Muhammad Aminat who the whistleblower alleged would bring into the laboratory, a personal genotype machine and conduct medical test to enrich his pocket.
According to Umeh, “My HOD Laboratory Services, Mr. Haruna Muhammad Aminat and Head of Unit Mrs. Afolake Bello Saidat asked us to be collecting money from patients and their relatives remitting it to our senior colleague by name Abdul Mohammed for hospital services rendered instead of patients or their relatives making payments at the cash point or bank, which I asked patients to pay and bring receipts of payments.”
Documents obtained by SATELLITE TIMES show how the directive from the Chief Medical Director was brazenly violated. Secret log-book leaked to SATELLITE TIMES detailed records of cash collected from patients. Most times patients were extorted as monies they were made to pay were above official charges.
Quacks employed in the Haematology Unit
The whistleblower revealed that some members of staff in the haematology unit are not qualified, adding that they were ostensibly smuggled into the hospital employ just to play the money game.
Documents revealed that they were not licensed by the Medical Laboratory Science Council of Nigeria (MLSCN). The implications of unlicensed practitioners made to work in one of the most sensitive units of the hospital where blood samples are analysed know no bound.
The Whistleblower described the unlicensed staff members as “cover-up staffs”. Though not qualified to work in the laboratory, they are “untouchable”.
SATELLITE TIMES obtained a letter dated 31st May 2017 from the Medical Laboratory Science Council of Nigeria (MLSCN) to the Keffi Chapter of the Association of Medical Laboratory Scientists of Nigeria. Some staff members working as Medical Laboratory Scientists at FMC Keffi were considered as “either not qualified or are yet to be registered with MLSCN” as their names were not found in the MLSCN data base.
The letter from MLSCN named Namo Allu Fidelis and Lekshak Grace Sunday, emphasising that “the underlisted names were not found in our database which suggests that they are either not qualified or are yet to be registered with MLSCN”. The letter was signed by G.A Aikpitanyi-Iduitua, Deputy Director, Practitioners’ Regulation and Discipline.
The MLSCN is the National Medical Laboratory Accreditation Agency, a federal statutory body established by Act 11, 2003 which is responsible for the registration and licensing of Medical Scientists in Nigeria.
After Umeh squealed on the corrupt officers, he was first deployed from the haematology unit to the histopathology unit where his services were not needed.
Even after he had vigorously argued that he studied haematology and clinical chemistry and that he lacked the requisite knowledge and skill set to work in the histopathology unit, he was given a deaf ear. Histopathology is the study of changes in tissue caused by disease. Haematology, on the other hand, is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. The whistleblower is a trained haematologist.
After the redeployment to the Histopathology Unit where he was forced to work as a quack, to which he refused, Gabriel Umeh’s salary was stopped November 2017. Upon enquiry, the accounts department informed him his name had been removed from the schedule of payment in the Integrated Payroll and Personal Information System (IPPIS).
SATELLITE TIMES visited FMC Keffi seeking official response. The Chief Medical Director, Yahaya Baba Adamu, said he was only seven days on the job.“I am actually in the process of taking over. Unfortunately, I have not been able to get this privilege information since I arrived here” the new Chief Medical Director said.
Yahaya described Satellite Times investigation as, “something quite commendable” adding it was “an eye opener” as it will help him to widen his searchlight. He pledged for time to look into the allegations and clean up the system. That was on 12 July 2018.
Two months later, in September, SATELLITE TIMES returned to the hospital but met with hostilities from the secretary to the Chief Medical Director. This reporter was however able to speak to some patients who pleading anonymity lamented countless cases of corruption they had experienced in the hands of hospital officials.
Located some 52 kilometres from Abuja, the hospital’s proximity to the neighboring states of Benue, Plateau, Kaduna, Kogi and Niger, contributes to the increase in the number of referral cases to the FMC Keffi.
Yet another attempt was made by this newspaper in November to get an official response, this time from the Public Relation Officer, Mr. Abdullahi Mohammed. Speaking over the phone, he promised to get back but never did.
A staff member of the hospital (name withheld) corroborated the whistleblower’s story, adding that among the senior officials who sat in a group with the new Chief Medical Director inside his office to welcome SATELLITE TIMES in July, were actually those mentioned in the petition written by the whistleblower.
“How can the same people be in the group investigating their own case,” she quipped.
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